As described recently in Nanotechnology, researchers at Huazhong University of Science and Technology, China, have modified dendrimers with PEG of two different molecular weights and different number of chains. The results indicate that conjugation with PEG could effectively reduce the cell apoptosis by attenuating ROS production and inhibiting MMP collapse. Meanwhile, dendrimers conjugated with more PEG of higher molecular weight were seen to be much less cytotoxic.

This study provides an insight into the effects of PEGylation on cytotoxicity at molecular level. The strategy employed considerably functionalized dendrimers and the researchers have extended their work to investigate the effect of PEGylated dendrimers on haemocompatibility. A series of encouraging results will be reported soon.