The research group is dedicated to developing effective and universal strategies to fabricate various nanoparticle assemblies using biomolecules such as DNA and polysaccharides. The molecules are employed as bridges to assemble gold nanospheres, gold nanorods, metal nanoparticle/carbon nanotube hybrids and metal nanoparticle/graphene composites. By using biomolecules to fabricate nanostructures, the team aims to generate biomaterials with good stability in aqueous solutions and excellent biocompatibility for optical tracking and drug delivery in vivo.

In the current study, a polysaccharide derivate, polyaldehyde dextran, was used to synthesize and assemble Au-NPs in one step. As shown in the images above, Au-NP chains or networks were formed with satisfactory morphology and the size of individual nanoparticles was uniform. The crystal growth and self-assembly processes occurred synchronously in one pot and always under a mild condition (aqueous environment, physiological temperature and neutral pH).

Further details can be found in the journal Nanotechnology.