The scientists have looked at the effect of albumin-modified magnetic fluids consisting of magnetite nanoparticles and varying amounts of bovine serum albumin, which can be used to adjust the material's physico-chemical properties (hydrodynamic diameter, zeta potential and isoelectric point).

Therapeutic agent

Results indicate that incubation of insulin amyloid fibrils with albumin-modified magnetic fluid leads to the significant destruction of aggregates. The extent of the depolymerizing activity was affected by the amount of albumin used for magnetic fluid modification and mainly depends on the size of nanoparticles.

The team's findings represent a starting point for the application of active albumin-modified magnetic fluids as therapeutic agents targeting insulin amyloidosis.

More details can be found in the journal Nanotechnology.