The team from Wayne State University, US, is developing a "bone-like" nanofibrous scaffold that consists of polyvinyl alcohol (PVA), nano-hydroxyapatite (nHA) and collagen I (Col). PVA is a water-soluble polymer that performs well in electrospinning. However, PVA is bioinert and exhibits fast degradation in water, but this can be modified using additives. Embedding both nHA and Col into the PVA matrix provides a "bone-like" 3D structure that enhances the adhesion, proliferation and differentiation of osteoblast cells.

AFM analysis

The surface roughness and mechanical stiffness of PVA/HA/Col nanofibers were found to mimic the natural bone ECM microenvironment. Next, the potential effects in enhancing implant fixation will be invested in animal models.

Full details can be found in the journal Nanotechnology.