Researchers at the Indian Institute of Technology (IIT) Kharagpur have successfully fabricated fibroin-blended nanoparticles. The nanoparticles are small in size and stable for a longer period of time in different media. FITC-labeled nanoparticles are able to reach the cells and reside in perinuclear space without any cytotoxicity.

The nanomaterial shows higher drug (methotrexate) encapsulation, loading efficiency and delayed drug release. It interacts with the cells and is retained at the site of action for a longer period of time, which is advantageous for sustained release.

The fibroin-blended nanoparticles loaded with the methotrexate drug could be promising nanocarriers for delivery to target sites. The nanomaterial could also carry other hydrophobic therapeutic agents for delivery to specific sites.

More detailed information about the study can be found in the journal Nanotechnology.

This work is financially supported by the Department of Biotechnology, through its Bioinformatics SUB-DIC programme, Govt. of India, New Delhi.