Pluronic F127 (PF127) is an ABA-type triblock copolymer that presents high biocompatibility and an ideal surface modification of materials. It is highly safe in vivo and has been approved for use in intravenous drugs by the US Food and Drug Adminstration (FDA).

Transformation of the probe

Researchers from Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology in China transformed Bi2S3-PF127 nanoparticles from Bi2S3-OAm by stirring in the PF127 solution. Fourier transform infrared spectroscopy (FT-IR) spectra, transmission electron microscopy (TEM) and physical stability were used to characterize the modification.

Biocompatible and safe

The authors demonstrate in vitro and in vivo CT imaging using the Bi2S3-PF127 probe through phantom imaging, cell imaging and mouse imaging by the self-image system, which all show a good contrast effect. They then study the biological distribution of Bi by inductively coupled plasma atomic emission spectroscopy (ICP-AES). This confirms that most of the nanoparticles are cleaned out after injection by 48 hours and that the Bi2S3-PF127 probe has a long circulation. Hematoxylin and eosin stains, biochemical analysis and blood analysis confirm that the probe has good biocompatibility and safety.

More information can be found in the journal Nanotechnology 25 295103.

Further reading

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