Atomically thin MoS2 sheets are synthesized and isolated via solvent-assisted chemical exfoliation. Layered transition metal dichalcogenides are being extensively researched due to their structural similarities with graphene and interesting physico-chemical properties. This is in addition to their exotic electronic properties. MoS2 is an extensively studied material and has already shown promising applications in electronics and optoelectronics fields.

Overcoming interferents

Here, electrochemical enzymatic and non-enzymatic biosensing studies using ultrathin MoS2-based electrodes unravel the potential of these electrodes. DA always co-exists with its common interferent ascorbic acid (AA) and both of them undergo oxidation at a similar potential under physiological conditions. As the concentration of AA is always higher than that of DA, the reliable measurement and quantification of DA is difficult. The existence of surface negative charges on MoS2 discriminates or eliminates the interference of AA. An extensive study on various redox probes using MoS2 indicates that MoS2 electrodes can be extended to the selective detection of other charged biomolecules.

Favourable geometry

Further, it is demonstrated that the entire MoS2 surface is in a favourable geometry to accommodate enzymes, thereby opening up the possibility for highly sensitive enzymatic biosensing applications. Currently, the authors are investigating the possibility of designing flexible sensors using MoS2 sheets for point-of-care diagnosis.

More information about the research can be found in the journal Nanotechnology 25 335702.

Further reading

Tweaking the magnetism of molybdenum sulphide nanoribbons (Mar 2014)
Graphene nanonets make biological sensors (Sep 2013)