The researchers employ the principle of liquid exfoliation to obtain the 2D MoS2 nanosheets before they are assessed for their suitability for biological applications. They then investigate the cytotoxic effects on two important cells lines, rat adrenal medulla endothelial (RAMEC) cells and rat pheochromocytoma (PC 12) cells, using three different techniques.

Insignificant cytotoxic effects

Electrical impedance spectroscopy (EIS) results indicate that the resistance value remains the same before and after the addition of MoS2 nanosheets thereby confirming that the MoS2 nanosheets have insignificant cytotoxic effects. The researchers further confirm their findings by performing cytotoxic measurements using a sulforhodamine B (SRB) assay and confocal microscopy.

From these investigations, it is evident that these the MoS2 nanosheets are great potential candidates for many biological applications such as drug delivery, gene transfection, and bio-imaging.

More information about this research can be found in the journal Nanotechnology 26 315102.

Further reading

Nanographene oxide destroys tumours (Nov 2013)
Tweaking the magnetism of molybdenum sulphide nanoribbons (Mar 2014)
Mesoporous silica nanocomposite simplifies combination therapy (Jun 2014)