The approach includes the use of a continuous flow reactor and direct gas-phase electrophoresis for post-synthesis size classification and in situ characterization of mobility size. The method demonstrates the potential for the future scale-up of nanoparticle synthesis in the industrial process.

A multidisciplinary team, which includes researchers from the National Tsing Hua University and Industrial Technology Research Institute in Taiwan, studied the controlled synthesis of Ag-SiO2 hybrid nanostructures using the concept of gas-phase EISA. Results show that particle size, composition, and morphology of the Ag-SiO2 hybrid nanostructures are achieved on demand by choosing suitable precursor concentration plus utilizing the post-synthesis size classification.

Using Ag-SiO2 hybrid nanostructures, the performance in surface plasmon resonance, colloidal stability, and dispersion of AgNPs in an aqueous environment enhance significantly. The methodology provides the proof of concept to fabricate high-purity noble metal-based hybrid nanostructures for future biomedical applications (e.g., hyperthermal therapy, targeted drug delivery, and antibacterial applications).

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