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Product details

New low-volume disposable cuvette extends protein analysis capabilities of the Zetasizer® Nano Oct 1, 2007

Company details

Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
WR14 1XZ
United Kingdom

Tel: 01684 892456
Fax: 01684 892789

A new low volume disposable polystyrene cuvette for the Malvern® Zetasizer Nano S and ZS particle characterization systems enables the size measurement of as little as 40 microlitres of sample.

This is less than half the volume possible with previous disposable cuvettes and is thought to be the lowest volume disposable cuvette available for any dynamic light scattering system. Such low volume capabilities are especially important when analyzing biological materials where it is often necessary to use the smallest amount of material possible. The use of disposable systems offers both convenience and freedom from any risks of cross-contamination.

The new cuvettes, supplied with caps for a firm seal, are suitable for use in the analysis of aqueous samples such as proteins in solution, for which the Zetasizer Nano has become the system of choice. The cuvettes are also compatible with a range of alcohols, ketones, DMF and ethyl acetate. Samples can be stored in the freezer at -20ºC, and measurements made at up to 70 degrees C, for the determination of protein melting point. For those instances where analysis of even smaller volumes is required, reusable cuvettes for the Zetasizer Nano as small as 12 microlitres are available.

Malvern's Zetasizer Nano is the most widely used light scattering system for the size measurement of particles and molecules in solution. Designed to meet the low sample volume, high sensitivity requirements essential for protein characterization, it is easy to use and measures molecules as small as 0.3 nm hydrodynamic radius. Established applications include protein size and molecular weight measurement, screening for protein crystallization conditions, determining aggregates and measuring melting points. Furthermore, size trends as a function of pH or additive concentration, for example, can be automated by coupling it to the MPT-2 autotitrator.


Malvern® and Zetasizer® are registered trademarks of Malvern Instruments Limited

High resolution image available from Trish Appleton, Kapler Communications Ref: MAL/JOB/1209

About Malvern Instruments
Malvern Instruments is a global company that develops, manufactures and markets advanced analytical systems used in characterizing a wide variety of materials, from bulk powders to the latest nanomaterials and delicate macromolecules. Innovative technologies and powerful software produce systems that deliver industrially relevant data enabling customers to make the connection between micro (eg particle size) and macro (bulk) material properties (rheology) and chemical composition (chemical imaging). Malvern laboratory, on-line and in-line solutions are proven in sectors from cement to pharmaceuticals and support the understanding, improvement and optimization of many industrial processes.

Headquartered in Malvern, UK, the company has subsidiary organizations in all major European markets, North America, China, Korea and Japan, key partnerships in India, a global distributor network and a number of applications laboratories around the world.

For press information, please contact
Trish Appleton
Kapler Communications
Knowledge Centre
Wyboston Lakes
Great North Road
MK44 3BY, UK
Tel: +44 (0)1480 479280;
Fax: +44 (0)1480 470343

USA contact:
Marisa Fraser
Malvern Instruments Inc
10 Southville Road
MA 01772, USA
Tel: +1 508 480 0200;
Fax: +1 508 460 9692

Please send sales enquiries to:
Alison Vines
Malvern Instruments Ltd
Enigma Business Park
Grovewood Road
Tel: +44 (0) 1684 892456;
Fax: +44 (0) 1684 892789